It’s unclear what causes statin side effects, especially muscle pain. The Mayo Clinic suggests that statins may affect not only your liver’s production of cholesterol but also several enzymes in muscle cells that are responsible for muscle growth, and that the effects of statins on these cells may be the cause of muscle aches.

Not everyone who takes a statin will have side effects, but some people may be at a greater risk than others. Among the acknowledged risk factors are:

  • Taking multiple medications to lower your cholesterol;
  • Being female;
  • Having a smaller body frame;
  • Being age 65 or older;
  • Having kidney or liver disease;
  • Drinking too much alcohol.

There are drugs and food that  may increase the risk of side effects when taking statins. Grapefruit juice, for example,  contains a chemical that can interfere with the enzymes that break down, or metabolize, the statins in your digestive system. You may not need to eliminate grapefruit entirely from your diet, but if you’re taking statins it would be wise to ask your doctor about how much grapefruit you can have.

Drugs that may interact with statins and increase your risk of side effects include:

  • Amiodarone (Cordarone, Pacerone), a medication for irregular heart rhythms;
  • Gemfibrozil (Lopid), another variety of cholesterol drug;
  • Protease inhibitors, such as saquinavir (Invirase) and ritonavir (Norvir);
  • Some antibiotic and antifungal medications, such as clarithromycin (Biaxin) and itraconazole (Onmel, Sporanox);
  • Some immunosuppressant medications, such as cyclosporine (Gengraf, Neoral, Sandimmune).

You can see how important it is that your doctor be aware of all the medicines you take when being prescribed with statins. (Allow us to point out here that Cholesterade© is not a statin: it contains soluble Acacia fiber, and a recent Harvard study has shown a direct link to diets high in soluble fiber and their ability to lower LDL cholesterol.)  One caution: Acacia  can prevent the body from absorbing the antibiotic amoxicillin (Amoxil, Trimox), so we suggest taking  Cholesterade at least four hours before or after taking amoxicillin.

Next: Can you relieve these side effects?